Alprenolol

SKU: orb1689972

Description

Alprenolol is a non-selective beta-adrenergic receptor antagonist that additionally blocks serotonin 5-HT1A and 5-HT1B receptors. It is used in research to investigate adrenergic and serotonergic signaling in cardiovascular and neurological studies, both in vitro and in animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13655-52-2
• MW: 249.35
• Purity: 99.78% (May vary between batches)
• Formula: C₁₅H₂₃NO₂
• SMILES: CC(C)NCC(O)COc1ccccc1CC=C
• Target: Adrenergic Receptor,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.02 mM);Ethanol:5 mg/mL (20.05 mM);DMSO:15 mg/mL (60.16 mM)

Bioactivity

• In Vivo:
  In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Item No. 10010494) and L-tryptophan . Alprenolol (10 μg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the β2-AR antagonist ICI 118551 in transgenic mice overexpressing the β2-AR . It also reduces the level of abnormal prion fibrils (PrPSc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L .
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• In Vitro:
  Alprenolol binds to β1-, β2-, and β3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and 5-HT1B receptors in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively) [1,2].
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alprenolol, Alpheprol, anti-anginal, anti-arrhythmic, anti-hypertensive, Adrenergic Receptor, AdrenergicReceptor, 5HT Receptor, 5-HT Receptor, 5-HT1A, 5-HT1B, 5-HT, 5HTReceptor, (RS)-Alprenolol, dl-Alprenolol, β-adrenoceptor, β-adrenergic receptor

Compound Identifiers

PubChem CID

2119