Alprenolol hydrochloride

SKU: orb1220036

Description

Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13707-88-5
• MW: 285.81
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄ClNO₂
• SMILES: Cl.CC(C)NCC(O)COc1ccccc1CC=C
• Target: 5-HT Receptor
• Solubility: DMSO:95 mg/mL (332.39 mM; Need ultrasonic); H2O:50 mg/mL (174.94 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Alprenolol (p.o. , 50 mg/kg) hydrochloride causes a significant drop in blood pressure which averages 20 mm Hg (at 3-hr) and an increase in heart rate by 39 beats/min (at 3-hr) in conscious renal hypertensive dogs. Alprenolol (i.p. , 5 mg/kg) hydrochloride effectively blockes the anxiolytic effects of indorenate and ipsapirone but do not reduce the motor activity in adult male Swiss Webster mice. Alprenolol (intravenous injection, 0.5 or 1.0 mg/kg) can decrease systolic pressure by a mean of 10 mm Hg, diastolic pressure by a mean of 10 mm Hg) hydrochloride and heart rate by 23 beats/min, as well as slightly reduce both myocardial and liver blood flows by mean of 17% and 15% respectively at a dose of 1.0 mg/kg in cats.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor