alpha-Naphthoflavone

SKU: orb1221978

Description

Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

Key Properties

• CAS Number: 604-59-1
• MW: 272.3
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₂O₂
• SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
• Target: Aromatase
• Solubility: In Vitro: DMSO : 25 mg/mL (91.81 mM)

Bioactivity

• In Vivo:
  Animal model: HFD-induced mice model. Dosage: 80, 160 mg/kg. Administration: i. g. Result: Decreased the levels of AST, TG and TC.
• In Vitro:
  Cell Proliferation Assay Cell line: HeLa. Concentration: 0.01, 1, 10, 100 μM Incubation time: 6 days. Result: Decreased cell proliferation in a dose-dependent manner with IC50 value of 36.81 μM. Apoptosis Analysis Cell line: HeLa. Concentration: 50 μM. Incubation time: 12, 24, 36 h. Result: Induced a mild but significant apoptosis rate. Western blot analysis. Cell line: HeLa. Concentration: 50 μM. Incubation time: 12, 24, 36 h. Result: Increased the level of p53 at 12 h.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Aromatase