alpha-Mangostin

SKU: orb1307648

Description

Alpha-Mangostin is a xanthonoid compound derived from the mangosteen tree. It is widely used in research for its biological activities, with applications in studies of inflammation, cancer, and oxidative stress in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 6147-11-1
• MW: 410.46
• Purity: 99.84% (May vary between batches)
• Formula: C₂₄H₂₆O₆
• SMILES: C(C=C(C)C)C1=C2C(OC=3C(C2=O)=C(O)C(CC=C(C)C)=C(O)C3)=CC(O)=C1OC
• Target: Dehydrogenase,Virus Protease,ROS,Antifungal,Reactive Oxygen Species,Antibacterial,Apoptosis
• Solubility: DMSO:252.5 mg/mL (615.16 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.87 mM)

Bioactivity

• Target IC50:
  IDH1 (mutant, R132H):2.85 μM(ki)
• In Vivo:
  Alpha-mangostin mitigates the risk of liver fibrosis by diminishing p53 expression relative to TAA_DMSO treatment. Moreover, following α-mangostin administration, serum concentrations of liver enzymes AST and ALT are reduced in comparison to treatment with DMSO alone.
• In Vitro:
  Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin.
• Cell Research:
  IDH1+/+ and IDH1

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

alphaMangostin, alpha-Mangostin, Apoptosis, alpha Mangostin, a-Mangostin, Bacterial, IDH1-R132H, Mangostin, Fungal, inhibit, Inhibitor, α-Mangostin, VirusProtease, Virus Protease, Reactive Oxygen Species, ReactiveOxygenSpecies

Compound Identifiers

PubChem CID

5281650