alpha-Boswellic acid

SKU: orb1222232

Description

Boswellic acid promotes induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.

Key Properties

• CAS Number: 471-66-9
• MW: 456.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₈O₃
• SMILES: CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1
• Target: Others
• Solubility: In Vitro: DMSO : 25 mg/mL (54.74 mM)

Bioactivity

• In Vivo:
  Animal model: 2, 4-Dinitrochlorobenzene-Induced Atopic-like Dermatitis in BALB/c Mice. Dosage: 3 or 10 mg/kg. Administration: i.p. Result: Reduced the severity of the AD-like symptoms. Attenuated the increase in ear thickness and decreased cutaneous TEWL in DNCB-treated mice. Animal model: Ethanol-induced gastric injury in rats. Dosage: 200 mg/kg. Administration: i. g. Result: Reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner. Increased the expression of both Nrf2 and HO-1.
• In Vitro:
  RT-PCR Cell line: HaCaT. Concentration: 1, 3, 10 μM. Incubation time: 20 min. Result: Decreased IL-1β, IL-6, IL-8, MDC, and TARC mRNA expression. Increased the mRNA expression of involucrin, filaggrin, and loricrin in TNF-α/IFN-γ-induced cells. Western blot analysis. Cell line: HaCaT. Concentration: 1, 3, 10 μM. Incubation time: 20 min. Result: Inhibited ERK, p38, and JNK protein phosphorylation. Reduced the phosphorylated NF-κB protein levels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Boswellic acid

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Gene Symbol

Others