Aloperine

SKU: orb1222037

Description

Aloperine is an alkaloid with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions. It inhibits HIV-1 replication and envelope-mediated cell-cell fusion in vitro. Aloperine also inhibits the growth of HL-60, U937, and K562 leukemia cell lines.

Key Properties

• CAS Number: 56293-29-9
• MW: 232.36
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄N₂
• SMILES: C1CCN2C[C@H]3C[C@@H]([C@H]2C1)C=C1[C@H]3NCCC1
• Target: Others
• Solubility: In Vitro: DMSO : 5.56 mg/mL (23.93 mM)

Bioactivity

• In Vitro:
  Aloperine (1-20 μM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM, respectively. Aloperine (1-20 μM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells. Aloperine (20-100 μM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aloperine

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