Aloin(mixture of A&B)

SKU: orb1301590

Description

This small molecule inhibitor, Aloin, suppresses IL-1β-induced IL-8 production in KB oral epithelial cells. It is a useful research tool for studying inflammatory pathways, particularly in models of oral mucositis and periodontitis, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 8015-61-0
• MW: 418.398
• Purity: 99.36%
• Formula: C₂₁H₂₂O₉
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc12
• Target: IL Receptor,MMP,Antibacterial,Antifungal
• Solubility: DMSO:50 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL

Bioactivity

• In Vivo:
  Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases.
• In Vitro:
  Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins. Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively. Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs).
• Animal Research:
  Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Aloin(mixture of A&B), Fungal, Matrix metalloproteinases, Inhibitor, inhibit, IL Receptor, ILReceptor, MMP

Compound Identifiers

PubChem CID

9866696