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Aloin

SKU: orb1305085

Description

Aloin (a mixture of Aloin A and B) is a natural anthraquinone glycoside isolated from Aloe vera. It acts as a tyrosinase inhibitor and is widely used in biochemical research to study melanogenesis and skin depigmentation mechanisms in both in vitro and in vivo models.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number1415-73-2
MW418.39
Purity99.89% (May vary between batches)
FormulaC21H22O9
SMILESOCC1OC(C(O)C(O)C1O)C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(CO)C=C2O
TargetTyrosinase
SolubilityH2O:1 mg/mL (2.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.39 mM);Ethanol:2 mg/mL (4.78 mM);DMSO:4.19 mg/mL (10.01 mM)

Bioactivity

In Vivo
In the MCF-7 cell line, Aloin induces apoptosis and decreases the proportion of cells in mitosis by inhibiting the expression of Topoisomerase IIα and downregulating Cyclin B1. In HeLaS3 cells, Aloin exhibits significant antiproliferative effects at physiological concentrations (IC50=97 μM), leading to cell cycle arrest in the S phase and a marked increase in apoptosis.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Aloin-A, Barbalin, Barbaloin, Barbaloin-A, tyrosinase

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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50 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
100 mg
$ 100.00
DispatchUsually dispatched within 5-10 working days
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