Aloin

SKU: orb1305085

Description

Aloin (a mixture of Aloin A and B) is a natural anthraquinone glycoside isolated from Aloe vera. It acts as a tyrosinase inhibitor and is widely used in biochemical research to study melanogenesis and skin depigmentation mechanisms in both in vitro and in vivo models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1415-73-2
• MW: 418.39
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₂₂O₉
• SMILES: OCC1OC(C(O)C(O)C1O)C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(CO)C=C2O
• Target: Tyrosinase
• Solubility: H2O:1 mg/mL (2.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.39 mM);Ethanol:2 mg/mL (4.78 mM);DMSO:4.19 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  In the MCF-7 cell line, Aloin induces apoptosis and decreases the proportion of cells in mitosis by inhibiting the expression of Topoisomerase IIα and downregulating Cyclin B1. In HeLaS3 cells, Aloin exhibits significant antiproliferative effects at physiological concentrations (IC50=97 μM), leading to cell cycle arrest in the S phase and a marked increase in apoptosis.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aloin-A, Barbalin, Barbaloin, Barbaloin-A, tyrosinase

Compound Identifiers

PubChem CID

313325