Alogliptin Benzoate

SKU: orb1305540

Description

Alogliptin Benzoate

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 850649-62-6
• MW: 461.51
• Purity: 99.95%
• Formula: C₂₅H₂₇N₅O₄
• SMILES: Cn1c(=O)cc(n(c1=O)Cc1ccccc1C#N)N1CCC[C@H](C1)N.c1ccc(cc1)C(=O)O
• Target: Ferroptosis,Proteasome,DPP-4
• Solubility: H2O:2 mg/mL (4.33 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (119.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.17 mM)

Bioactivity

• Target IC50:
  DPP4:<10 nM
• In Vivo:
  Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats. Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion.
• In Vitro:
  Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alogliptin Benzoate, Alogliptin(SYR-322)benzoate, Alogliptin, DPP, DPP4, DPP-4, Dipeptidyl Peptidase, diabetes, Inhibitor, Ferroptosis, inhibit, SYR 322, SYR322, SYR-322

Compound Identifiers

PubChem CID

16088021