Aloe-emodin-8-O-β-D-glucopyranoside

SKU: orb1297582

Description

Aloe-emodin-8-O-β-D-glucopyranoside is a bioactive compound demonstrating moderate in vitro inhibition of human Protein Tyrosine Phosphatase 1B (hPTP1B). This activity suggests its potential utility as a research tool in studies related to diabetes and metabolic disorders, where PTP1B is a validated therapeutic target.

Research Area

Metabolism Research

Key Properties

• CAS Number: 33037-46-6
• MW: 432.38
• Purity: 99.91% (May vary between batches)
• Formula: C₂₁H₂₀O₁₀
• SMILES: OC[C@H]1O[C@@H](Oc2cccc3C(=O)c4cc(CO)cc(O)c4C(=O)c23)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Phosphatase
• Solubility: DMSO:9 mg/mL (20.82 mM)

Bioactivity

• Target IC50:
  PTP1B (human):IC50: 26.6 μM
• In Vitro:
  A new lignan glycoside, named 1,5-dihydroxypinoresinol-4'-O-beta-d-glucopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-beta-D-glucopyranoside (2), fraxiresinol-4'-O-beta-D-glucopyranoside (3), (-)-olivil-4''-O-beta-D-glucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-beta-D-glucopyranoside, syringin, costunolide-15-O-beta-D-glucopyranoside, chlorogenic acid, Aloe-emodin-8-O-beta-D-glucopyranoside (5), rhein-8-O-beta-D-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, beta-costic acid, reynosin, arbusculin A, alpha-cyclocostunolide, beta-cyclocostunolide, santamarine and magnolialide.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PTP1B, Phosphatase, Aloe-emodin-8-O-beta-D-glucopyranoside, Aloeemodin8OβDglucopyranoside, Aloe-emodin-8-O-β-D-glucopyranoside, Aloe emodin 8 O β D glucopyranoside, Aloe-emodin-8-O-b-D-glucopyranoside, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5317644