Almonertinib

SKU: orb1301771

Description

Almonertinib (HS-10296) is a selective EGFR tyrosine kinase inhibitor that potently targets EGFR activation and T790M resistance mutations while sparing wild-type EGFR. It is widely used in preclinical research, demonstrating efficacy in both in vitro assays and in vivo models of non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1899921-05-1
• MW: 525.64
• Purity: 99.99% (May vary between batches)
• Formula: C₃₀H₃₅N₇O₂
• SMILES: COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C2CC2)c2ccccc12
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.51 mM);H2O:Insoluble;Ethanol:6 mg/mL (11.41 mM);DMSO:54.55 mg/mL (103.78 mM)

Bioactivity

• Target IC50:
  EGFR (L858R/T790M):0.29 nM (IC50)|EGFR (T790M):0.37 nM (IC50)|EGFR (del19/T790M):0.21 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

del19, cell, antineoplastic, cancer, Almonertinib, HS 10296, HS10296, HS-10296, L858R, L861Q, Inhibitor, HER1, G719X, Epidermal growth factor receptor, EGFR, EGFR (E746_A750/T790M), ErbB-1, lung, NSCLC, oral, non-small, inhibit, mutations

Compound Identifiers

PubChem CID

121280087