Alloxan monohydrate

SKU: orb1299481

Description

Alloxan monohydrate is a proteasome inhibitor used to induce experimental diabetes models. It selectively damages pancreatic β-cells, impairing insulin secretion. This compound is widely applied in diabetes research for establishing both in vivo animal models and in vitro β-cell toxicity studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 2244-11-3
• MW: 160.09
• Purity: 99.01% (May vary between batches)
• Formula: C₄H₄N₂O₅
• SMILES: O.O=C1NC(=O)C(=O)C(=O)N1
• Target: Proteasome
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.49 mM);DMSO:60 mg/mL (374.79 mM)

Bioactivity

• In Vitro:
  Alloxan caused the accumulation of ubiquitinated proteins in NRK cells through the inhibition of the proteolytic activities of the proteasome. Alloxan directly acts on the chymotrypsin- and trypsin-like peptidase activities

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

insulin, Inhibitor, inhibit, diabetes, diabetogenic agent, Alloxan, Alloxan monohydrate, Alloxan Monohydrate, 26S, 20S proteasomes, B cells, Proteasome

Compound Identifiers

PubChem CID

16723