Allethrin

SKU: orb1305382

Description

Allethrin

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 584-79-2
• MW: 302.41
• Purity: 99.52% (May vary between batches)
• Formula: C₁₉H₂₆O₃
• SMILES: CC(C)=CC1C(C(=O)OC2CC(=O)C(CC=C)=C2C)C1(C)C
• Target: Bcl-2 Family,Apoptosis,Caspase
• Solubility: DMSO:60 mg/mL (198.41 mM)

Bioactivity

• In Vivo:
  In male wistar rats aged 90 day,s Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days) increased lipid peroxidation in the caput, cauda, and testes. Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg. GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg. GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats.
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• In Vitro:
  Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium. Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, calcium, Caspase-3, Bcl-2, Allethrin, inhibit, Pyrethroid, oxidative, maturation, mosquito, insecticide, Inhibitor, epididymis, stress, testis, repellent, release, sperm

Compound Identifiers

PubChem CID

11442