ALK/ROS1-IN-5

SKU: orb2945421

Description

ALK/ROS1-IN-5 (X4) is a potent, selective dual inhibitor of ALK and ROS1 kinases, demonstrating cellular activity with an IC50 of 0.034 μM in H2228 cells. It induces dose-dependent apoptosis and suppresses p-ALK and p-ERK signaling, supporting its application in oncology research for studying ALK/ROS1-driven cancers in vitro.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• MW: 554.586
• Formula: C₃₂H₂₈F₂N₄O₃
• SMILES: COC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)N6CCOCC6
• Target: Apoptosis,ROS Kinase,ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676978