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ALK/EGFR-IN-2

SKU: orb1944271

Description

ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells. It effectively suppresses proliferation in H1975, PC9, and Baf3-EML4-ALK cancer cell lines, with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2730432-75-2
MW572.12
FormulaC27H34ClN7O3S
SMILESN(CCN(C)C)(C)C1=C(NC(C=C)=O)C=C(NC=2N=C(NC3=C(S(CC)=O)C=CC=C3)C(Cl)=CN2)C(OC)=C1
TargetOthers,ALK

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

ALK/EGFR-IN-2 (orb1944271)

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