ALKBH5-IN-3

SKU: orb2695229

Description

ALKBH5-IN-3 is a potent and selective ALKBH5 demethylase inhibitor with an IC50 of 21 nM. It stabilizes the ALKBH5 protein and increases cellular m6A RNA methylation, making it a valuable chemical probe for studying m6A biology in cancer and epigenetics research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1505579-77-0
• MW: 272.18
• Purity: 98.32% (May vary between batches)
• Formula: C₁₁H₇F₃N₂O₃
• SMILES: O=C(O)C1=NN(C(O)=C1)C2=CC=CC(=C2)C(F)(F)F
• Target: ALK
• Solubility: DMSO:24 mg/mL (88.18 mM)

Bioactivity

• Target IC50:
  ALKBH5:21 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

83557584