(-)-Alkannin

SKU: orb1302417

Description

(-)-Alkannin (Shikonin) is a bioactive naphthoquinone with documented antimicrobial, antitumor, and anti-inflammatory properties. It is utilized in pharmaceutical, cosmetic, and food applications, and research indicates it inhibits viability and metastasis in gastric cancer cells via TLR2/NF-κB pathways in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 517-88-4
• MW: 288.3
• Purity: 98.80%
• Formula: C₁₆H₁₆O₅
• SMILES: CC(C)=CC[C@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Target: PI3K,Apoptosis
• Solubility: DMSO:50 mg/mL (173.43 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.94 mM)

Bioactivity

• In Vitro:
  3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Cell scratch repair experiments were conducted fo the determination of migration ability while transwell assay for cell invasion ability. Western blot analysis and real-time polymerase chain reaction assay were used fo the detection of protein and mRNA expressions. Fifty per cent inhibitory concentration of Shikonin on MGC-803 cells was 1.854 μM. Shikonin (1 μM) inhibited significantl the adhesion, invasion and migratory ability of MGC-803 cells. Interestingly, Shikonin in the presence or absence of anti-Toll-like receptor 2 (TLR2) antibody (2 μg) and nuclear factor-kappa B (NF-κB) inhibitor MG-132 (10 μM) could decrease these ability of MGC-803 cells markedly, as well a the expression levels of matrix metalloproteinases (MMP)-2, MMP-7, TLR2 and p65 NF-κB. In addition the co-incubation of Shikonin and anti-TLR2 mg-132 has a significant stronger activity than anti-TLR2 or MG-132 alone.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Apoptosis, Alkannin, ()Alkannin, ( ) Alkannin, PI3Kα, Shikonin

Compound Identifiers

PubChem CID

72521