ALK5-IN-83

SKU: orb2695518

Description

ALK5-IN-83 (compound 13b) is a potent ALK5 inhibitor (IC50 = 0.13 µM) that effectively blocks TGF-β1-induced Smad2 phosphorylation and inhibits cell migration in A549 lung cancer cells. This tool compound is suitable for investigating TGF-β signaling in fibrosis and cancer metastasis research, both in vitro and in vivo.

Research Area

Cell Biology, Stem Cell & Developmental Biology

Key Properties

• MW: 425.51
• Formula: C₂₀H₂₃N₇O₂S
• SMILES: O=C(NC1=C(Br)C=C(C=C1C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)C2=CC=CC(=C2F)N(C(=O)C3=CC=C(F)C=C3)CC4CC4
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

141746946