ALK2-IN-2

SKU: orb1710458

Description

ALK2-IN-2 is a highly selective small molecule inhibitor of activin receptor-like kinase 2 (ALK2), demonstrating potent activity with an IC50 of 9 nM and exhibiting over 700-fold selectivity against ALK3. This inhibitor is a valuable chemical probe for studying BMP signaling in fibrodysplasia ossificans progressiva (FOP) and other disorders, supporting both in vitro biochemical assays and in vivo disease model research.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2254409-25-9
• MW: 497.61
• Purity: 99.55% (May vary between batches)
• Formula: C₂₈H₂₇N₅O₂S
• SMILES: CC(N1CCCC1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccc(c2ccccc12)S(N)(=O)=O
• Target: ALK,TGF-beta/Smad
• Solubility: DMSO:112.5 mg/mL (226.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.04 mM)

Bioactivity

• Target IC50:
  ALK2:9 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TGFb, TGF-b/Smad, TGFbeta, TGF-beta, TGFbeta/Smad, Smad, TGF-β Receptor, TGF-β/Smad, TGFβ, ALK3, ALK2, ALK2 IN 2, ALK2IN2, ALK-2-IN-2, ALK2-IN-2

Compound Identifiers

PubChem CID

138454752