ALK-IN-35

SKU: orb3211233

Description

ALK-IN-35 is an ALK degrader with an IC50 of 0.74 nM. It inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes the formation of partially unfolded ALK conformations, and induces proteasome-mediated degradation of ALK. ALK-IN-35 effectively inhibits cancer cell proliferation and is applicable in research related to non-small-cell lung cancer.

Key Properties

• CAS Number: 3111011-76-5
• MW: 690.21
• Formula: C₃₆H₄₅ClN₇O₃P
• SMILES: O=C(N1CCN(CC1)C2CCN(C3=CC=C(NC4=NC=C(Cl)C(=N4)NC=5C=CC=CC5P(=O)(C)C)C(OC)=C3)CC2)C6CC7C=CC6C7
• Target: ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ALK