ALK-IN-31

SKU: orb3027997

Description

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3043840-25-8
• MW: 527.68
• Formula: C₃₀H₃₃N₅O₂S
• SMILES: O=C1C2=CC=C(C=C2CCC1)NC=3N=C(NC=4C=CC=CC4NC(=O)C5CCCCC5)C6=C(N3)CCSC6
• Target: ALK,Akt,mTOR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ALK,Akt,mTOR,Apoptosis