ALK-IN-27

SKU: orb1941625

Description

Neladalkib (NVL-655) is a brain-penetrant and selective ALK inhibitor that targets diverse oncogenic ALK mutants. It is a research tool for studying non-small cell lung cancer (NSCLC), demonstrating antitumor efficacy in both cellular assays and in vivo preclinical models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2739866-40-9
• MW: 452.91
• Purity: 99.71% (May vary between batches)
• Formula: C₂₃H₂₂ClFN₆O
• SMILES: C(C)N1C2=C(CC=3C(C=4C([C@@H](C)OC=5C=C2C=NC5N)=CC(F)=CC4)=NN(C)C3)C(Cl)=N1
• Target: ALK,Apoptosis
• Solubility: DMSO:80 mg/mL(176.64 mM)

Bioactivity

• Target IC50:
  Ba/F3 CLIP1-LTK cells:2.7 nM
• In Vitro:
  Neladalkib is a potent ALK inhibitor with antitumor activity. Neladalkib has an IC50 = 2.7 nM for Ba/F3 CLIP1-LTK cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALK-IN-27, ALK, NVL 655, NVL655, NVL-655

Compound Identifiers

PubChem CID

164718816