Aliskiren hemifumarate

SKU: orb1308348

Description

Aliskiren hemifumarate

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 173334-58-2
• MW: 1219.6
• Purity: 96.18% (May vary between batches)
• Formula: C₃₀H₅₃N₃O₆·1/2C₄H₄O₄
• SMILES: C(=O)(/C=C/C(=O)O)O.C(=O)([C@@H](C[C@@H]([C@H](C[C@@H](C(C)C)Cc1cc(c(cc1)OC)OCCCOC)N)O)C(C)C)NCC(C(=O)N)(C)C.C(=O)([C@@H](C[C@@H]([C@H](C[C@@H](C(C)C)Cc1cc(c(cc1)OC)OCCCOC)N)O)C(C)C)NCC(C(=O)N)(C)C
• Target: RAAS,Autophagy
• Solubility: H2O:92 mg/mL (75.43 mM);DMSO:93 mg/mL (76.25 mM);Ethanol:93 mg/mL (76.25 mM)

Bioactivity

• Target IC50:
  Renin:1.5 nM
• In Vitro:
  Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aliskiren, Aliskiren hemifumarate, Aliskiren Hemifumarate, C26, cachexia, cancer, cardiovascular diseases, Autophagy, CGP 60536, CGP 60536 hemifumarate, CGP60536, CGP-60536, CGP60536B, CGP60536B hemifumarate, colon carcinoma, inhibit, Inhibitor, Hypertension, SPP100, SPP-100, SPP 100, SPP 100 hemifumarate, Renin

Compound Identifiers

PubChem CID

6918427