Alisertib Sodium

SKU: orb1692016

Description

Alisertib Sodium is a potent and selective Aurora A kinase inhibitor that induces mitotic arrest and apoptosis in tumor cells by disrupting chromosomal alignment. It also suppresses STAT3 phosphorylation and c-Myc expression. This small molecule has demonstrated antitumor activity in both cellular assays and in vivo xenograft models across various cancer research fields.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1028486-06-7
• MW: 540.91
• Purity: 99.77% (May vary between batches)
• Formula: C₂₇H₁₉ClFN₄NaO₄
• SMILES: O=C(C1=CC=C(NC2=NC(C3=C(C(C4=C(OC)C=CC=C4F)=NC5)C=C(Cl)C=C3)=C5C=N2)C=C1OC)[O-].[Na+]
• Target: Others,Aurora Kinase,STAT,Apoptosis,Autophagy

Bioactivity

• Target IC50:
  Aurora B:396.5 nM|Aurora A:12.5 nM
• In Vivo:
  Methods: To investigate the inhibitory effect of Alisertib Sodium (MLN 8237 Sodium) on colorectal tumor growth, a HCT-116 colon cancer xenograft model was established in nude mice. Mice were administered Alisertib orally at doses of 3, 10, or 30 mg/kg once daily for 3 consecutive weeks. Results: Alisertib Sodium significantly inhibited tumor growth in a dose-dependent manner. The tumor growth inhibition (TGI) rates for the 3, 10, and 30 mg/kg groups were 43.3%, 84.2%, and 94.7%, respectively .
• In Vitro:
  Methods: The anti-proliferative activity of Alisertib Sodium (MLN 8237 Sodium) was evaluated in various tumor cell lines. Cells were treated with the compound in vitro, and cell proliferation was measured to determine IC₅₀ values. Results: Alisertib Sodium exhibited significant anti-proliferative effects across different tumor cell lines, with IC₅₀ values ranging from 15 to 469 nM, indicating cell line-dependent sensitivity differences .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alisertib sodium

Compound Identifiers

PubChem CID

66819786