Alfuzosin

SKU: orb1909164

Description

Alfuzosin (SL 77499) is an orally available, competitive α1-adrenoceptor antagonist.Alfuzosin induces smooth muscle relaxation in the bladder neck and prostate.Alfuzosin has been used to study benign prostatic hypertrophy, lower urinary tract symptoms (LUTS), and ejaculatory dysfunction (EjD).

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 81403-80-7
• MW: 389.45
• Purity: 99.64%
• Formula: C₁₉H₂₇N₅O₄
• SMILES: COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.42 mM);DMSO:40 mg/mL (102.71 mM)

Bioactivity

• In Vivo:
  In Male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; Single dose) increases prostatic concentration to 4.1-8.6 times higher than plasma concentratio.
• In Vitro:
  In Male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; Single dose) increased prostatic concentration to 4.1-8.6 times higher than plasma concentratio.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

AdrenergicReceptor, Adrenergic Receptor, SL 77499, α1A-adrenergic receptor

Compound Identifiers

PubChem CID

2092