Alfuzosin

SKU: orb1909164

Description

Alfuzosin is a selective α1-adrenoceptor antagonist that relaxes smooth muscle in the lower urinary tract. It is widely used in research models of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), including investigations into bladder function and ejaculatory physiology in both in vitro and in vivo studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 81403-80-7
• MW: 389.45
• Purity: 99.64% (May vary between batches)
• Formula: C₁₉H₂₇N₅O₄
• SMILES: COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.42 mM);DMSO:40 mg/mL (102.71 mM)

Bioactivity

• In Vivo:
  In male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; single dose) increases prostatic concentrations to 4.1-8.6 times higher than plasma concentration.
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• In Vitro:
  In male Wistar rats weighing 250-450 g, Alfuzosin (10 mg/kg; oral administration; single dose) increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AdrenergicReceptor, Adrenergic Receptor, SL 77499, α1A-adrenergic receptor

Compound Identifiers

PubChem CID

2092