Alfacalcidol

SKU: orb1223128

Description

Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism.

Key Properties

• CAS Number: 41294-56-8
• MW: 400.64
• Purity: >98% (HPLC)
• Formula: C₂₇H₄₄O₂
• SMILES: [H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CCC\C2=C\C=C1/C[C@@H](O)C[C@H](O)C1=C
• Target: Others
• Solubility: DMSO : ≥ 50 mg/mL. 124.80 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: Female Wistar-Imamichi rats (8 months old), ovariectomized. Dosage: 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg. Administration: Oral administration; five times a week; for 3 months. Result: Exerted bone-protective effects independently of its Ca-related effects.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-hydroxycholecalciferol | 1.alpha.-Hydroxyvitamin D3

Quick Database Links

Gene Symbol

Others