Alendronate sodium trihydrate

SKU: orb1300824

Description

Alendronate sodium hydrate is a nitrogenous bisphosphonate that potently inhibits osteoclast-mediated bone resorption. It is widely used in osteoporosis research, with established applications in both in vitro assays of osteoclast activity and in vivo models for studying bone density and fracture prevention.

Research Area

Metabolism Research

Key Properties

• CAS Number: 121268-17-5
• MW: 325.12
• Purity: 99.90% (May vary between batches)
• Formula: C₄H₁₂NO₇P₂·3H₂O·Na
• SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.O.[Na+].O.O
• Target: Others,Transferase
• Solubility: DMSO:Slightly soluble;H2O:28.57 mg/mL (87.88 mM)

Bioactivity

• Target IC50:
  FPPS:460 nM.
• In Vivo:
  Sodium alendronate primarily inhibits the rate-limiting step in the cholesterol biosynthesis pathway within osteoclasts. Lowering the levels of farnesyl pyrophosphate interferes with protein prenylation and concurrently inhibits the biosynthesis pathway of isoprenoids. Additionally, sodium alendronate acts to suppress sterol in osteoclasts.
• In Vitro:
  In mice, pretreatment with 0.1 mg/kg of Alendronate one to two times a week, in combination with 10-50 mg/kg of paclitaxel, effectively inhibits the growth of PC-3 ML tumors in bone marrow and soft tissue, significantly extending survival times to 4-5 weeks. In rats, Alendronate exacerbates indomethacin-induced gastric damage and delays the healing of gastric ulcers. In rabbits, Alendronate causes gastric erosion and increases the incidence and area of indomethacin-induced antral ulcers.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Farnesyl diphosphate synthase, G704650, G-704650 Adronat, G 704650, MK217, MK-217, Alendronate sodium

Compound Identifiers

PubChem CID

23681107