ALE-0540

SKU: orb1685304

Description

ALE-0540 is a small molecule inhibitor that selectively blocks NGF binding to both its p75 and TrkA receptors, thereby disrupting downstream TrkA-mediated signaling and biological activity. This tool compound is used in vitro and in vivo to investigate neurotrophin pathways in pain, neurodegeneration, and cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 234779-34-1
• MW: 301.25
• Purity: 99.88% (May vary between batches)
• Formula: C₁₄H₁₁N₃O₅
• SMILES: O=C1C=2C=3C(C(=O)N1NCCO)=CC=CC3C=C(N(=O)=O)C2
• Target: Others,Trk receptor
• Solubility: DMSO:50 mg/mL (165.98 mM)

Bioactivity

• In Vivo:
  Either i.p. or i.th. administration of ALE-0540 in rats produced antiallodynia in the L5/L6 ligation model of neuropathic pain. The calculated A50 values (and 95% confidence intervals) for ALE-0540 administered i.p. and i.th. were 38 (17.5–83) mg/kg and 34.6 (17.3–69.4) mg, respectively. ALE-0540 given i.th., at doses of 30 and 60 mg, also blocked tactile allodynia in the thermal sensitization model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Trk receptor, TrkA, Trkreceptor, ALE 0540, ALE0540, ALE-0540

Compound Identifiers

PubChem CID

2826530