Aldoxorubicin hydrochloride

SKU: orb1709836

Description

Aldoxorubicin hydrochloride

Research Area

Molecular Biology

Key Properties

• CAS Number: 1361563-03-2
• MW: 787.21
• Purity: 99.86% (May vary between batches)
• Formula: C₃₇H₄₃ClN₄O₁₃
• SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](\C(=N\NC(CCCCCN4C(=O)C=CC4=O)=O)\CO)(O)C2)C(O)=C5C1C(=O)C=6C(C5=O)=C(OC)C=CC6.Cl
• Target: Topoisomerase,ADC Cytotoxin
• Solubility: DMSO:127.5 mg/mL (161.96 mM)

Bioactivity

• In Vivo:
  Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) significantly reduces tumor volumes and IgG levels by day 28, showing high tolerability with a 90% survival rate in mice with LAGκ-1A tumors . It demonstrates a favorable safety profile at doses up to 260 mg/mL doxorubicin equivalents, effectively inducing tumor regression in breast cancer, small cell lung cancer, and sarcoma during a phase I study . Additionally, it outperforms doxorubicin in murine renal cell carcinoma and breast carcinoma xenograft models .
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• In Vitro:
  Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

topoisomerase II, Aldoxorubicin Hydrochloride, Aldoxorubicin hydrochloride (1361644-26-9 Free base), 1361644-26-9, 1361644-26-9 Free base

Compound Identifiers

PubChem CID

10056071