ALDH3A1-IN-4

SKU: orb3209956

Description

ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma models, where ALDH3A1-IN-4 is used to investigate aldehyde dehydrogenase-dependent detoxification pathways, enzyme–ligand binding interactions, and differential cellular response mechanisms in tumor versus non-tumor cellular systems.

Key Properties

• CAS Number: 324777-01-7
• MW: 290.31
• Purity: 99.98% (May vary between batches)
• Formula: C₁₄H₁₁FN₂O₂S
• SMILES: O=S(=O)(C1=CC=C(F)C=C1)N2C=3C=CC=CC3N=C2C
• Target: Dehydrogenase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dehydrogenase