Albendazole

SKU: orb1309592

Description

Albendazole (SKF-62979) is a broad-spectrum anthelmintic compound used in research to study parasitic worm infections. It is widely applied in both in vitro and in vivo experimental models to investigate mechanisms of action, drug efficacy, and resistance in parasitology.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 54965-21-8
• MW: 265.33
• Purity: 99.53% (May vary between batches)
• Formula: C₁₂H₁₅N₃O₂S
• SMILES: N(C(OC)=O)C=1NC=2C(N1)=CC(SCCC)=CC2
• Target: Antibiotic,Autophagy,Parasite,Microtubule Associated,ROS,Reactive Oxygen Species,HIF/HIF Prolyl-Hydroxylase,Antibacterial,VEGFR,Apoptosis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:1 mg/mL (3.77 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:10 mg/mL (37.69 mM)

Bioactivity

• In Vivo:
  Albendazole and its sulfoxide metabolites induce the accumulation of cells in the mitotic phase.
• In Vitro:
  In sheep lambs administered Albendazole intravenously, the drug and its active metabolite, albendazole sulfoxide, are recovered in tapeworms. In rats, Albendazole significantly increases hepatic activity: it induces a 65-fold increase in CYP1A1-related ethoxyresorufin O-deethylase (EROD) activity, a 6-fold increase in CYP1A2-related methoxyresorufin O-demethylase activity, a 4-fold increase in CYP2B1-related pentoxyresorufin O-dealkylase activity, a 14-fold increase in CYP2B2-related benzyloxyresorufin O-dealkylase activity, and also leads to a partial reduction in CYP2E1-related p-nitrophenol hydroxylase activity. Albendazole is metabolized by liver and lung microsomes in sheep and cattle as well as bovine intestinal microsomes into its pharmacologically active sulfoxide metabolite.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

caspase-3, Albendazole, Autophagy, Apoptosis, Antibiotic, inhibit, Inhibitor, Microtubule/Tubulin, microtubule, Microtubule Associated, MicrotubuleAssociated, Parasite, parasiticide, PARP, Hypoxia-inducible factors, LC3, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF-PH, HIFs, HIFProlylHydroxylase, HIF ProlylHydroxylase, HIF, Echinococcus granulosus, SKF62979, SKF-62979, SKF 62979, tapeworm, Reactive Oxygen Species, Vascular endothelial growth factor receptor, VEGFR, VEGF

Compound Identifiers

PubChem CID

2082