Alagebrium chloride

SKU: orb1300033

Description

Alagebrium chloride

Research Area

Metabolism Research

Key Properties

• CAS Number: 341028-37-3
• MW: 267.77
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₁₄ClNOS
• SMILES: [Cl-].Cc1sc[n+](CC(=O)c2ccccc2)c1C
• Target: Endogenous Metabolite
• Solubility: DMSO:83.33 mg/mL (311.2 mM)

Bioactivity

• In Vivo:
  Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation.
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• Animal Research:
  Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs. This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ. Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced. After 4 weeks, the animals were sacrificed for histological analysis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALT711, ALT-711, ALT 711, Alagebrium, Alagebrium chloride, Alagebrium Chloride, AGE, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite

Compound Identifiers

PubChem CID

216306