AKT1-IN-11, a derivative of Podophyllotoxin, functions as a dual inhibitor of AKT1 and tubulin. It reduces phosphorylation levels of AKT kinase in tumor cells, disrupts cell proliferation, causes G2/M phase arrest, and induces apoptosis. Additionally, AKT1-IN-11 promotes tubulin depolymerization and is applicable in colorectal cancer research.