AKT Kinase Inhibitor

SKU: orb1710464

Description

AKT Kinase Inhibitor is a selective small molecule that suppresses cell proliferation in a dose-dependent manner, demonstrating antitumor properties. It is widely used in cancer research to study the PI3K/AKT signaling pathway in both cellular and animal models, aiding in the investigation of tumor growth and survival mechanisms.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 842148-40-7
• MW: 357.37
• Purity: 99.37% (May vary between batches)
• Formula: C₁₆H₁₉N₇O₃
• SMILES: C(C)N1C=2C(=C(C#CCO)N=CC2OCCCN)N=C1C=3C(N)=NON3
• Target: Akt
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.8 mM);DMSO:10 mg/mL (27.98 mM)

Bioactivity

• Target IC50:
  Akt3:9 nM|Akt2:13 nM|Akt:2.5 µM|Akt1:2 nM|GSK-3β:43-150 nM
• In Vivo:
  METHODS: In an animal model, subcutaneously injected Trop-2-expressing tumors were treated with specific drugs that inhibit Akt activity. RESULTS Tumor growth was significantly reduced and Akt played a central functional role in mediating Trop-2-dependent growth stimulation.
• In Vitro:
  METHODS: The proliferative effect of cells expressing Trop-2 was observed by silencing or inhibiting Akt with specific drugs. RESULTS The proliferative effect of cells expressing Trop-2 was significantly reduced in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, AKT Kinase Inhibitor

Compound Identifiers

PubChem CID

25023726