AKT-I-1

SKU: orb1305387

Description

AKT-I-1 is a potent, cell-permeable small molecule that selectively and reversibly inhibits the Akt1 kinase. It is widely used in cancer research to study PI3K/Akt signaling pathways in both cellular and animal models of tumorigenesis and therapeutic resistance.

Research Area

Signal Transduction

Key Properties

• CAS Number: 473382-39-7
• MW: 378.51
• Purity: 99.89%
• Formula: C₂₂H₃₀N₆
• SMILES: CN(C)CC(C)(C)CNc1nn2c(nnc2cc1C1CCC1)-c1ccccc1
• Target: Akt
• Solubility: DMSO:1.43 mg/mL (3.78 mM)

Bioactivity

• Target IC50:
  Akt2:>250 μM|Akt1:4.6 μM|Akt3:>250 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AKTI1, AKT-I-1, AKT I 1, Akt1

Compound Identifiers

PubChem CID

10271028