AKR1C3-IN-4

SKU: orb1303635

Description

AKR1C3-IN-4 is a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), exhibiting an IC50 of 0.56 µM. This compound is a valuable research tool for studying castrate-resistant prostate cancer (CRPC), with applications in both in vitro enzymatic assays and in vivo xenograft models to investigate androgen biosynthesis pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1284180-11-5
• MW: 281.23
• Purity: 98.84% (May vary between batches)
• Formula: C₁₄H₁₀F₃NO₂
• SMILES: OC(=O)c1cccc(Nc2ccc(cc2)C(F)(F)F)c1
• Target: Dehydrogenase,NADPH
• Solubility: DMSO:100 mg/mL (355.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.22 mM)

Bioactivity

• Target IC50:
  AKR1C3:0.56 μM (IC50)|AKR1C2:15.1 μM (IC50)
• In Vitro:
  The IC50 of AKR1C3-IN-4 for AKR1C2 is 15.1 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

resistant, prostate, reductase, castrate, CRPC, cancer, AKR1C2, AKR1C3, AKR1C3 IN 4, AKR1C3IN4, aldo-keto, AKR-1C3-IN-4, AKR1C3-IN-4, 1C3, Inhibitor, inhibit

Compound Identifiers

PubChem CID

51346826