AKB-6899

SKU: orb1304777

Description

AKB-6899 is a PHD3 inhibitor that stabilizes HIF-2α, thereby enhancing sVEGFR-1 production in macrophages. This mechanism has been shown to suppress tumor growth in vivo, making it a valuable research tool for studying hypoxia signaling, tumor immunology, and angiogenesis in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1007377-55-0
• MW: 290.25
• Purity: 97.87% (May vary between batches)
• Formula: C₁₄H₁₁FN₂O₄
• SMILES: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1
• Target: HIF,HIF/HIF Prolyl-Hydroxylase,VEGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.37 mM);DMSO:95 mg/mL (327.3 mM)

Bioactivity

• In Vivo:
  In C57BL/6 mice injected with B16F10 murine melanoma cells, AKB-6899 (17.5 mg/kg; i.p.) significantly reduces tumor growth.
• In Vitro:
  In murine bone marrow-derived macrophages, AKB-6899 (10 μM; 24 hours) increases the levels of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 shows no effect on HIF-1α accumulation or VEGF production.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hypoxia-inducible factors, HIFs, HIF-PH, HIFProlylHydroxylase, HIF-2α, HIF ProlylHydroxylase, HIF, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, Inhibitor, inhibit, antiangiogenic, antitumor, AKB 6899, AKB6899, AKB-6899, PHD3, sVEGFR-1, VEGFR1

Compound Identifiers

PubChem CID

49848485