Ajugol

SKU: orb1303739

Description

Ajugol (Leonuride) exhibits in vitro trypanocidal activity against Trypanosoma brucei rhodesiense, with reported IC50 values ranging from 29.3 to 73.0 µg/ml. This small molecule is a candidate for research in parasitology and neglected tropical disease drug discovery, primarily for mechanistic and anti-protozoal studies.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 52949-83-4
• MW: 348.35
• Purity: 99.65%
• Formula: C₁₅H₂₄O₉
• SMILES: [H][C@@]12C=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@]1([H])[C@@](C)(O)C[C@H]2O
• Target: Interleukin,mTOR,ROS,Parasite,Autophagy
• Solubility: DMSO:40 mg/mL (114.83 mM)

Bioactivity

• Target IC50:
  T. brucei rhodesiense:29.3–73.0 ug/ml

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ajugol, Inhibitor, inhibit, iridoid, Parasite, glycoside, Leonuride, lepidota, Trypanosoma, Scrophularia

Compound Identifiers

PubChem CID

6325127