AIM-100

SKU: orb1302098

Description

AIM-100 is a potent small molecule inhibitor of the Ack1 kinase, demonstrating an IC50 of 24 nM. It is a valuable research tool for studying Ack1 signaling in cancer cell proliferation and migration through in vitro assays.

Research Area

Signal Transduction

Key Properties

• CAS Number: 873305-35-2
• MW: 371.43
• Purity: 98.75%
• Formula: C₂₃H₂₁N₃O₂
• SMILES: C(Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1)C1CCCO1
• Target: ACK1
• Solubility: DMSO:60 mg/mL (161.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM);Ethanol:30 mg/mL (80.77 mM)

Bioactivity

• Target IC50:
  Ack1:24 nM
• In Vitro:
  AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase . It also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors . AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ack1, ACK1, Activated Cdc42 kinase 1, AIM 100, AIM100, AIM-100, anticancer, ATM, inhibit, Inhibitor, NKX3.1, TMPRSS2, PSA, TNK2, Tyr-phosphorylation, Tyr267

Compound Identifiers

PubChem CID

58603315