AICAR phosphate

SKU: orb1707700

Description

AICAR phosphate

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 681006-28-0
• MW: 356.228
• Purity: 99.80%
• Formula: C₉H₁₄N₄O₅.xH₃O₄P
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(N)=C(C(N)=O)N=C2.P(=O)(O)(O)O xH3O4P
• Target: Autophagy,YAP,NOS,AMPK,Mitophagy,Endogenous Metabolite
• Solubility: DMSO:75 mg/mL;H2O:80 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL

Bioactivity

• In Vivo:
  Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle.
• In Vitro:
  HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YAP, iNOS, Mitophagy, Acadesine phosphate, AICA Riboside phosphate, Autophagy, AMPK

Compound Identifiers

PubChem CID

67675098