AGX51

SKU: orb1310015

Description

AGX51 is a small molecule antagonist that targets Inhibitor of DNA Binding (ID) proteins, inducing their pan-degradation. This action results in cell cycle arrest and apoptosis, making it a useful research tool for studying ID protein function in cancer and developmental biology in both cellular and animal models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 330834-54-3
• MW: 431.52
• Purity: 99.85% (May vary between batches)
• Formula: C₂₇H₂₉NO₄
• SMILES: CCC(=O)N(CCC(c1ccc2OCOc2c1)c1ccccc1OC)Cc1ccccc1
• Target: Others
• Solubility: DMSO:250 mg/mL (579.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.65 mM);Ethanol:95 mg/mL (220.15 mM)

Bioactivity

• In Vitro:
  AGX51 inhibits the Id1-E47 interaction. AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization. AGX51 may have utility in the management of multiple diseases.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, inhibitor of DNA binding (ID), anti-tumor, AGX 51, AGX51, AGX-51, TNBC, ubiquitin

Compound Identifiers

PubChem CID

2920302