AGW-11

SKU: orb3173148

Description

AGW-11 is a potent dual inhibitor that targets EGFR (IC50 = 556 nM) and VEGFR2 (IC50 = 289.7 nM). It induces apoptosis and inhibits the phosphorylation of EGFR, VEGFR2, and ERK1/2 in HUVECs. AGW-11 effectively suppresses cancer cell growth, reduces HUVEC proliferation, tube formation, and invasion, thus blocking angiogenesis. In 4T1 xenograft mouse models, AGW-11 significantly inhibits tumor growth and reduces lung metastasis. AGW-11 is applicable in breast cancer research.

Key Properties

• Target: VEGFR,Apoptosis,ERK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

VEGFR,Apoptosis,ERK,EGFR