AGPS-IN-2i

SKU: orb1739795

Description

AGPS-IN-2i is a high-affinity alkylglycerol phosphate synthase inhibitor that depletes cellular ether lipids. This tool compound has been utilized in vitro to study ether lipid metabolism's role in cancer cell migration, proliferation, and motility.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 2316782-88-2
• MW: 345.34
• Formula: C₁₈H₁₇F₂N₃O₂
• SMILES: C(NC(CC(C)C1=C(F)C=CC=C1F)=O)C=2C=C3C(=CC2)NC(=O)N3
• Target: MMP
• Solubility: DMSO:22.5 mg/mL (65.15 mM)

Bioactivity

• In Vitro:
  AGPS-IN-2i (2i) (500 µM ; 24 h) reduced ether lipids levels and cell migration rate In 231MFP cancer cells. 2i (50、100 µM ; 24 h) specifically impaired epithelial to mesenchymal transition (EMT) by modulating E-cadherin, Snail, and MMP2 expression levels in PC-3 and MDA-MB-231 cancer cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP-2, alkylglycerol phosphate synthase, AGPS-IN-2i, BMS 986318, BMS986318

Compound Identifiers

PubChem CID

155559442