AGN 192870

SKU: orb2900819

Description

AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism. AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Key Properties

• CAS Number: 166977-57-7
• MW: 378.46
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₂O₂
• SMILES: CC1(C)C=2C(C(=CC1)C3=CC=CC=C3)=CC(C#CC4=CC=C(C(O)=O)C=C4)=CC2
• Target: Apoptosis
• Solubility: In Vitro: DMSO : 6.25 mg/mL (16.51 mM; Ultrasonic (<60°C)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis