AGK7

SKU: orb1306117

Description

AGK7 is an inactive structural analog of the SIRT2 inhibitor AGK2. It serves as a negative control compound in studies investigating sirtuin biology, particularly for SIRT2 and SIRT3, which are implicated in metabolic regulation, neurodegeneration, and cancer research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 304896-21-7
• MW: 434.27
• Purity: 98.31% (May vary between batches)
• Formula: C₂₃H₁₃Cl₂N₃O₂
• SMILES: ClC1=CC=C(Cl)C(=C1)C1=CC=C(O1)\C=C(/C#N)C(=O)NC1=C2N=CC=CC2=CC=C1
• Target: Sirtuin
• Solubility: DMSO:0.5 mg/mL (1.15 mM)

Bioactivity

• In Vitro:
  AGK2 is a selective SIRT2 inhibitor with IC50 value of 3.5 μM. AGK2 slightly inhibited SIRT1 and 3 only at concentrations over 40 μM. Relative to an inactive control AGK7, AGK2 increased acetylated tubulin. In H4 cells transfected with α-Syn, AGK2 reduced α-Syn-mediated toxicity in a dose-dependent way. By contrast, the inactive AGK7 had no effect. In H4 cells cotransfected withα-Syn and synphilin-1, the inactive AGK7 failed to affect a-Syn aggregation, whereas AGK2 promoted the formation of enlarged inclusions .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirtuin, sirtuin 2, SIRT2 Inhibitor,Inactive Control, toxicity, Inhibitor, morphology, inhibit, Parkinson's disease, alpha-synuclein, AGK 7, AGK7, AGK-7, Drosophila, dopaminergic cell death

Compound Identifiers

PubChem CID

1372572