AGI-24512

SKU: orb1707707

Description

AGI-24512 is a potent and selective MAT2A inhibitor (IC50: 8 nM) with antiproliferative effects in MTAP-deficient cancer cells. Its mechanism, which induces DNA damage, supports its use in both in vitro and in vivo studies exploring novel combination therapies for oncology research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2201066-53-5
• MW: 400.47
• Purity: 98.55% (May vary between batches)
• Formula: C₂₄H₂₄N₄O₂
• SMILES: Cc1[nH]c2c(N3CCCCC3)c(nn2c(=O)c1-c1ccc(O)cc1)-c1ccccc1
• Target: DNA,Methionine Adenosyltransferase (MAT)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM);DMSO:80 mg/mL (199.77 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  MAT2A inhibitor AGI-24512 showed poor bioavailability and short half-life in rats.
• In Vitro:
  MAT2A inhibitor AGI-24512 significantly blocked the proliferation of MTAP-deficient cancer cells in vitro.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S-adenosylmethionine Synthetase, PRMT5, HCT116, MAT2A, MATA2, MTAP, methylthioadenosine phosphorylase, Methionine Adenosyltransferase (MAT), anticancer, antiproliferative, AGI 24512, AGI24512, AGI-24512, DNA damage response, DNA

Compound Identifiers

PubChem CID

134307780