AGF347

SKU: orb3174969

Description

AGF347 is a potent multitarget antifolate that acts on serine hydroxymethyltransferase (SHMT)2 located in mitochondria and SHMT1 in the cytoplasm, while inhibiting de novo purine synthesis. This compound induces apoptosis, suppresses the mTOR signaling pathway, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS) production. AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates antitumor activity in SKOV3 EOC xenograft mouse models. It is a valuable agent for ovarian cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2294820-23-6
• MW: 473.46
• Formula: C₂₂H₂₄FN₅O₆
• SMILES: C(CCCC1=CC(F)=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C1)N2C3=C(C=C2)NC(N)=NC3=O
• Target: Apoptosis,Mitochondrial Metabolism,ROS,mTOR,Antifolate

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Mitochondrial Metabolism,ROS,mTOR,Antifolate