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AGB-374

SKU: orb3210775

Description

AGB-374 is an orally active NDUFS7 inhibitor. It destabilizes the NDUFS7 protein and inhibits oxidative phosphorylation by targeting mitochondrial complex I. In vivo, AGB-374 reduces MYC protein levels in colon cancer cells and slows tumor growth in homologous mouse models of colon cancer. AGB-374 synergistically enhances the cytotoxicity of copper chelators against cancer cells and downregulates MYC and NDUFS7 protein levels in these cells when used in combination with copper chelators. AGB-374 is useful for colon cancer research.

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Key Properties

Targetc-Myc

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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