AG18

SKU: orb1226858

Description

AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.

Key Properties

• CAS Number: 118409-57-7
• MW: 186.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₆N₂O₂
• SMILES: N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
• Target: EGFR
• Solubility: Ethanol: 37 mg/mL (198.74 mM); DMSO: 37 mg/mL (198.74 mM)

Bioactivity

• In Vitro:
  10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1 μM ghrelin. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG-50810 | RG-50858 | TX 825 | Tyrphostin 23 | Tyrphostin AG-18

Quick Database Links

Gene Symbol

EGFR