AG-012986

SKU: orb1740284

Description

AG-012986 is a potent and selective multi-CDK inhibitor targeting CDK1, 2, 4/6, 5, and 9. It demonstrates robust in vitro antiproliferative activity and induces significant tumor growth inhibition in vivo across multiple human xenograft models, associated with Rb hypophosphorylation, cell cycle arrest, and apoptosis. This profile supports its research use in oncology, particularly for studying cell cycle dysregulation and evaluating CDK inhibition as a therapeutic strategy.

Research Area

Cell Biology

Key Properties

• CAS Number: 486414-35-1
• MW: 459.51
• Formula: C₂₂H₂₃F₂N₅O₂S
• SMILES: C(=O)(C=1SC(NC2=CC=C(C(N[C@@H](CN(C)C)C)=O)C=C2)=NC1N)C3=C(F)C=CC=C3F
• Target: Others,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11259686